Optimization, characterization and biological effect of Algerian propolis

Natural products was the source of many important biological activities against human and animal pathogens. Propolis one these substances, produced by bees from resins wax. In this study, D-optimal experimental design used to optimize operational condition propolis extraction, then phenolic compounds extracted seven regions Bejaia identified quantified HPLC analysis. Also, their evaluated, including antibacterial, antifungal, antioxidant, anti-inflammatory effects, sperm cells cryopreservation effect. The highest antibacterial activitywas obtained in extract Baccaro region B. cereus strong effect S. areus, C. albicans, E. Coliwas reached using Melbou region. High inhibition percentage denaturation BSA protein observed Melbou. best antioxidant preservation This work demonstrates that agitation method (MEA) showed strongest indicating an interesting promising approach for development new therapeutics formulations based on bejaia